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KMID : 0624620130460090460
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BMB Reports
2013 Volume.46 No. 9 p.460 ~ p.464
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Induction of transforming growth factor-beta 1 by androgen is mediated by reactive oxygen species in hair follicle dermal papilla cells
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Shin Hyo-Seung
Yoo Hyeon-Gyeong
Inui Shigeki
Itami Satoshi
Kim In-Gyu
Cho A-Ri
Lee Dong-Hun
Park Won-Seok
Kwon Oh-Sang
Cho Kwang-Hyun
Won Chong-Hyun
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Abstract
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The progression of androgenetic alopecia is closely related to androgen-inducible transforming growth factor (TGF)-β1 secretion by hair follicle dermal papilla cells (DPCs) in bald scalp. Physiological levels of androgen exposure were reported to increase reactive oxygen species (ROS) generation. In this study, rat vibrissae dermal papilla cells (DP-6) transfected with androgen receptor showed increased ROS production following androgen treatment. We confirmed that TGF-β1 secretion is increased by androgen treatment in DP-6, whereas androgen-inducible TGF-β1 was significantly suppressed by the ROS-scavenger, N-acetyl cysteine. Therefore, we suggest that induction of TGF-β1 by androgen is mediated by ROS in hair follicle DPCs.
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KEYWORD
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Androgenetic alopecia, Androgen receptor, Dermal papilla, Reactive oxygen species, Transforming growth factors
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